منابع مشابه
Molecular dynamics simulation of Angiotensin I: precursor of Angiotensin II
Hypertension or high blood pressure is one of the threatening problems in the world nowadays. The renin-angiotensin system (RAS) or the renin angiotensin aldosterone system (RAAS) helps to regulate long term blood pressure and extra cellular volume in the body. The system can be activated when there is a loss of blood volume or a drop in blood pressure. AngiotensinI (Ang I) is an oligopeptide, ...
متن کاملMolecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides
Angiotensin-I converting enzyme (ACE), a two-domain dipeptidylcarboxypeptidase, is a key regulator of blood pressure as a result of its critical role in the renin-angiotensin-aldosterone and kallikrein-kinin systems. Hence it is an important drug target in the treatment of cardiovascular diseases. ACE is primarily known for its ability to cleave angiotensin I (Ang I) to the vasoactive octapepti...
متن کاملAngiotensin I-converting enzyme isoforms (high and low molecular weight) in urine of premature and full-term infants.
Angiotensin I-converting enzyme (ACE) isoforms in urine from healthy and mildly hypertensive untreated patients have been described in the literature. Healthy subjects have high- and low-molecular-weight ACEs (170 and 65 kDa), whereas mildly hypertensive untreated patients have only low-molecular-weight ACEs (90 and 65 kDa), both of which resemble ACE from the N-terminal domain. Previous studie...
متن کاملTwo putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning.
The amino-terminal amino acid sequence and several internal peptide sequences of angiotensin I-converting enzyme (ACE; peptidyl-dipeptidase A, kininase II; EC 3.4.15.1) purified from human kidney were used to design oligonucleotide probes. The nucleotide sequence of ACE mRNA was determined by molecular cloning of the DNA complementary to the human vascular endothelial cell ACE mRNA. The complet...
متن کاملHigh molecular weight derivatives of human fibrinogen produced by plasmin. I. Physicochemical and immunological characterization.
Two high molecular weight derivatives of fibrinogen (Fragments X and Y) produced by plasmin digestion have been identified by comparative analyses of the digests in agar, agarose, and acrylamide electrophoresis, immunoelectrophoresis, Sephadex G-ZOO gel filtration, and analytical ultracentrifugation. These fragments were purified by salt precipitation and Sephadex G-200 gel fltration and their ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1972
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)45742-6